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Naunyn-Schmiedeberg s Archives of Pharmacology

Chlorogenic acid is a P450 enzyme inhibitor, which can decrease the expression of CYP2E1 and CYP1A2 (Pang et al., 2015)

These isoforms are involved in the cerebral uptake of leptin, mainly in brain areas related to energy and adipose tissue metabolism, thereby contributing to the development of obesity