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Details on how aggresomes are eliminated from cells, however, remain a poorly understood facet of proteostasis

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1 Bioactive molecules like schisantherin A modulate apoptosis-related proteins and increase the expression of neuroprotective molecules like heme oxygenase 1 (HO-1)

Protein concentrations were determined using a BCA assay (Beyotime, P0009)

This condition affects multiple organs, including the skin, liver, gastrointestinal tract, lungs, kidneys, thymus, lymph nodes, bone marrow, and central nervous system, and is categorized into grades I-IV according to its severity, typically manifesting weeks to months post-HSCT