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Therapeutic treatment of a novel selective jak3/jak1/tbk1 inhibitor, cs12192, in rat and mouse models of rheumatoid arthritis

The metabolic activation leads to the activation of DNA adducts which if escapes the repair mechanism can result in miscoding and permanent mutation

Overall 32.2% of subjects had LH at only one site, and 65.8% of patients had LH at several site levels, primarily the abdomen (52.4%), followed by thighs (23.2%), arms (19.9%), and other unusual areas (4.5%), including the thigh area located immediately distal to the crural region, the areas immediately above the knee, and the proximal arm region (34.2%)

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