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Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IB kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3- thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and antigen-induced T cell proliferation

[300 301 302] AKI has also been associated with longer term harmful outcomes, such as increased odds of death, increased length of hospital stay, and an average of approximately $7,500 in excess hospital costs

178,179,180 In 2004, the FDA approved the first aptamer drug, pegaptanib (Macugen), to treat choroidal neovascularization caused by neovascular age-related macular degeneration (AMD)

10.1016/j.mam.2008.08.006 26 FriedmanJ

doi: 10.1016/j.neuron.2019.12.007 118 UllandTKSongWMHuangSCUlrichJDSergushichevABeattyWLet al

Histological assessments showed that Lv-siPDE5-ADSC treatment resulted in higher smooth muscle content and improved cavernous tissue recovery, with significantly enhanced smooth muscle/collagen ratios compared to unmodified ADSCs