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Semaglutide 2.4 mg (Wegovy) demonstrated 14.9% mean body weight loss versus 2.4% for placebo at 68 weeks in the STEP 1 trial (N=1,961) [7]

AMPK receptors can desensitize with chronic activation, reducing MOTS-c efficacy over time

Keremi et al., 2009

Those include B-cells, the cells responsible for making antibodies

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