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In cancer, PIN1 is frequently overexpressed 19,23 and APC CDH1 frequently inactivated through phosphorylation 7,9,13 , creating a wide therapeutic window for combined inhibition of CDK4 and PIN1

Cobo 2007)

de Guglielmo G, Kallupi M, Scuppa G, Stopponi S, Demopulos G, Gaitanaris G, Ciccocioppo R (2014) Analgesic tolerance to morphine is regulated by PPAR

9,10 In 1978, Rutter proposed new diagnostic criteria for autism emphasizing social skill dysfunction, language and communication impairment, and repetitive behaviours as three aspects of the basic criteria, abandoning the special skills and attractive appearance of Kanners criteria

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