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A study indicates that regular overdose of isolated vitamin B12 supplements, especially among male smokers, may increase the risk of lung cancer (Brasky et al., 2017)

Despite all the above, cyano B12 is the most prescribed form

The elimination half-life (t1/2) is 16.8 hours

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Why certain patients require more frequent treatment is not understood

For instance, those with severe vitamin B12 deficiency may require weekly or biweekly shots until their blood levels return to normal