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10.1371/journal.pone.0088319 185 YangD.YangZ.ChenL.KuangD.ZouY.LiJ.et al (2020)

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HEALTH-PROTECTIVE POTENTIAL OF SUPPLEMENTAL GLYCINE In addition to its role as a glutathione precursor, glycine is a substrate in the synthesis of porphyrins (heme), purines, creatine, sarcosine, and bile salts.23 Glycine constitutes approximately one-third of the amino acids in collagen and elastin and, hence, is a prominent component of connective tissues and the extracellular matrix

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In a phase 1 safety trial, GDNF delivered directly into patients putamen (Fig