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The endothelium regulates vascular tone, circulation of blood cells, vascular permeability, inflammation, and hemostasis by controlling the fine balance between vasodilatory and vasoconstrictory, pro-proliferative and anti-proliferative, pro-thrombotic and anti-thrombotic, pro-oxidant and antioxidant, fibrinolytic and anti-fibrinolytic, and pro-inflammatory and anti-inflammatory responses (23)

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Alvarez, M.-N