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Total symptom score decreased significantly compared to placebo across treatment groups of all doses 600-1800 mg/d oral ALA, yet there was a dose-dependent increase in nausea, vomiting, and vertigo, and therefore the lowest dose of oral ALA (600 mg/d) is recommended

Carnitine supplementation has shown promise in improving sperm motility and morphology in idiopathic infertility cases, while its role in antioxidant defense highlights its therapeutic potential in oxidative-stress-related reproductive disorders

Therefore, it appears that long-term supplementation is a required before effects become apparent

That said, it is helpful to monitor thyroid and carnitine levels when taking L-carnitine not because problems are expected, but because monitoring is good clinical practice when adding any supplement that has a theoretical interaction pathway

Sahakitrungruang T, Wacharasindhu S, Yeetong P, Snabboon T, Suphapeetiporn K, Shotelersuk V

The risk did not vary substantially by age (5-100 years) in the clinical trials analyzed