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The E3 ubiquitin ligase RNF31 mediates the development of ulcerative colitis by regulating NLRP3 inflammasome activation

In the gourami, OAB occurred at 35 dpf in normoxia (21 kPa PO 2 ), but severe intermittent nocturnal hypoxia (14 kPa PO 2 ) delayed appearance of this developmental maker by several days (Figure 4A)