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Presently, isatuximab is approved for the treatment of RRMM in combined therapy with pomalidomide and dexamethasone [79] and, in patients who have undergone two prior therapies, in combination with carfilzomib and dexamethasone [80]

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GSTs are divided into 14 classes: phi (GSTF), tau (GSTU), theta (GSTT), zeta (GSTZ), lambda (GSTL), metaxin, hemerythrin (GSTH), iota (GSTI), glutathione-dependent dehydroascorbate reductase (DHAR), tetrachloro hydroquinone dehalogenase (TCHQD), -subunit classes of the eukaryotic translation elongation factor 1B (EF1B), glutathionyl hydroquinone reductase (GHR), GSTs with two thioredoxins (GST2N), and microsomal prostaglandin E synthase type 2 (mPGES2) 2,3

These vaccine responses support the further evaluation of this EEHV vaccine in young, immunologically nave elephants, which are the target population for protection against EEHV-HD through vaccination

60 Subsequent studies indicated that 1,25-(OH) 2 D 3 also induces the expression of A20, an anti-apoptotic protein that inhibits the activation of caspase-8 and caspase-3, as well as the JNK signaling pathway