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These variations are predominantly determined by external environmental factors rather than host genetic background (28), limiting both metabolite measurement reproducibility and clinical application reliability of biomarkers

In hepatocytes, oxalate overload caused mitochondrial dysfunction and lipid accumulation by inhibiting the transcription of peroxisome proliferator-activated receptor and blocking mitochondrial FAO

Disruption of neurovascular unit prior to motor neuron degeneration in amyotrophic lateral sclerosis

We demonstrate the power and potential of this strategy for the preparation of various challenging targets in the efficient chemical syntheses of -conotoxin SI peptide, RANTES protein from the chemokine family, EETI-II trypsin inhibitor knotted mini protein, plectasin antimicrobial peptide and the linaclotide peptide drug

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