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The following criteria were considered: Full economic evaluations: cost-utility analysis, cost-effectiveness analysis, cost-benefit analysis Economic evaluations reporting incremental cost-effectiveness ratios (i.e., cost per quality-adjusted life year/life years gained or cost per event avoided) Studies in patients with confirmed vitamin B12 deficiency Studies in English Abstracts were reviewed by a single reviewer and, for those studies meeting the eligibility criteria, full-text articles were obtained

doi: 10.1080/21623945.2016.1240137

Keep a close tab on your diet while consuming vitamins to ensure you are not consuming the same vitamin from multiple resources, leading to an overdose

This is harmless and does not indicate the treatment is ineffective