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Currently, lactate fulfills three key roles: it acts as the primary energy source, serves as a significant precursor for gluconeogenesis, and functions as signaling molecules with autocrine, paracrine, and endocrine-like actions, collectively referred to as lactormone [41]

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doi: 10.1016/j.immuni.2019.06.002 117 BalmerMLMaEHBantugGRGrahlertJPfisterSGlatterTet al

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Exercise-induced lactate activates G protein-coupled receptor 81 (GPR81), also known as hydroxy carboxylic acid receptor 1 and a selective lactate-sensing receptor, which is downregulated under atherogenic OS