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Studies have demonstrated that PHGDH overexpression enables breast cancer cells to redirect more glutamine into the tricarboxylic acid cycle via the SSP, thereby supporting rapid cell proliferation (68, 69)

Bibliography Centers for Disease Control and Prevention

Suppression of NADPH oxidase- and mitochondrion-derived superoxide by Notoginsenoside R1 protects against cerebral ischemia-reperfusion injury through estrogen receptor-dependent activation of Akt/Nrf2 pathways

Conflicts of interest Conflicts of Interest: SCR, JTF, AS, BL, PS, VT and JH declare none

Thus supplementation is often required to maintain healthy levels.

Br J Clin Pharmacol 86(5):880890