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A recent review highlighted concerns with IV use, including rare anaphylaxis and potential hepatotoxicity (PMC narrative review)

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Notably, this regulatory effect appears to be context-dependent

This may include lifestyle recommendations, physical therapy, and ongoing monitoring to maximize the benefits of the treatment

Its cytoprotective effects were first characterized in the GI tract, but subsequent research has extended these findings to tendons, ligaments, bone, muscle, and even neural tissue

Activated cisplatin enters the nucleus and results into the transcription of genes involved in anticancer activity