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All treatments are available only if deemed appropriate by a licensed medical professional following an online consultation

Importantly, functional B12 deficiency can sometimes coexist with high total B12 levels, especially in kidney disease, and may require additional testing with methylmalonic acid (MMA) or holotranscobalamin if deficiency is suspected clinically

THE TARGET CONCENTRATION APPROACH TO DESIGNING A RATIONAL DOSAGE REGIMEN A rational dosage regimen is based on the assumption that there is a target concentration that will produce the desired therapeutic effect

Most patients experience a staged response: improved energy and sleep within 1 week, reduced neuropathic pain by week 3-4, and enhanced cognitive function after 6-8 weeks

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Nevertheless, faeces in general tend to be a rich source of B12 that we certainly do not recommend but its a source of B12 for many animals and may explain why in predominantly vegetarian populations in areas lacking sanitation, poor people tend to have a better B12 status than the urban middle class (Sobczyska-Malefora et al., 2021)