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Metabolites or even short RNAs directly act on receptors and ion channels (GABA receptors, TLRs, TRP channels, acid-sensitive ion channels) expressed by nociceptive primary afferents, and induce nociceptor activation and sensitization (Lutz et al., 2014

(2017) 9(401):eaah6733

Although fluorescent ROS-sensitive dyes (e.g., dihydroethidium) and genetically encoded probes (e.g., Grx1-roCherry) allow postmortem ROS detection in animal models (Hosoi et al., 2019

eADO can be catabolized to inosine by adenosine deaminase (ADA) or transported into cells by the nucleoside transporters ENT1/2 or CNT1/2 (106)

Stolwijk, S.D

In another study that evaluated the effect of 6 g/m 2 (i.e., dosage based on body surface area) twice daily glutamine versus placebo (three weeks followed by three weeks washout) in 49 children and adolescents receiving vincristine for various cancers, glutamine-treated patients reported significantly greater improvements in sensory function and quality of life compared with placebo-treated patients (Sands 2017)