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Investigators are particularly interested in determining the mechanisms by which effects observed in murine models relate to broader mammalian metabolic regulation, and whether different experimental conditions (young vs aged models, healthy vs metabolically compromised states) show differential responses to NNMT inhibition

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Warnings and Precautions 5.1 Severe Optic Atrophy in Patients with Lebers Disease Patients with early Lebers disease (hereditary optic nerve atrophy) who were treated with vitamin B12 suffered severe and swift optic atrophy

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