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The same conclusion cannot be drawn from the comparatively fewer studies that investigated other classes of monoaminergic antidepressants

This interaction promotes M2 macrophage polarization, enhancing pro-tumorigenic phenotypes ( 4.3 Macrophage-ferroptosis immunometabolism Tumor-associated macrophages (TAMs) and ferroptotic cancer cells engage in a highly integrated, bidirectional metabolic dialogue that shapes immune outcomes and determines tumor ( + , increased transferrin receptor (TfR1) expression, and restricted ferroportin activity, thereby enriching the tumor microenvironment (TME) with redox-active iron ( Ferroptotic cancer cells reciprocally influence macrophage states by releasing DAMPs (HMGB1), oxidized phosphatidylethanolamines (SAPE-OOH), iron-loaded vesicles, and lipid peroxidation products that serve as signals to recruit, polarize, or reprogram macrophages ( Figure 5

QL is the guarantor of this work and, as such, has full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis

The demethylated metabolite of tramadol, o-desmethyl tramadol (desmetramadol) is a better agonist for opioid receptor whilst tramadol, particularly S,S-tramadol is specific to NE transport inhibition 56

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