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The Phase 2 ACT-AD trial (NCT04491006) in mild-to-moderate Alzheimers disease failed its primary endpoint in June 2022

produce metabolic products, such as lactic acid and antibiotic proteins, that directly inhibit the growth of pathogens and influence the activity of host immune cells

Hcy is metabolized mainly through the remethylation pathway and the transsulfuration pathway ( Figure 1 )

Urness et al., 2010)

Byrne BJ, Flanigan KM, Matesanz SE, Finkel RS, Waldrop MA, DAmbrosio ES, Johnson NE, Smith BK, Bnnemann C, Carrig S, et al

Interestingly, while GABA treatment does not significantly change glutamate levels, CBBBP treatment reduces them further, raising concerns regarding the potential negative impact on brain function with this specific treatment