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If left untreated, a B12 deficiency can lead to more severe health issues, including neurological damage

Avoid mixing copper peptides with strong, lowpH actives like highstrength vitamin C (ascorbic acid), aggressive AHAs/BHAs (glycolic, lactic, salicylic acid), and potent retinoids in the same step, as they can destabilize peptides or increase irritation

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Measurement of total vitamin B12 and holotranscobalamin, singly and in combination, in screening for metabolic vitamin B12 deficiency