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10.1002/anie.202007962 69 ZhouC.SuematsuN

These numbers are broadly comparable to semaglutide, but the intensity appears somewhat greater, likely because the glucagon component adds an additional source of gastrointestinal stimulation on top of the GLP-1 effects

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The used modes of administration (systemic and/or subcutaneous) are both relevant for routine administration to preterm infants, if/when ongoing clinical trials are successful (ClinicalTrials.gov Identifiers NCT03253263 and NCT01096784, using systemic infusion)

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Preliminary findings from these ongoing trials have shown that utilizing glutathione precursors (like high-dose N-acetylcysteine) successfully restores these brain glutathione levels, reduces markers of central nervous system oxidative stress, and significantly ameliorates the clinical symptoms of ME/CFS