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Cost to develop new pharmaceutical drug now exceeds $2.5 B

Oncogenic driver mutations in non-small cell lung cancer: past, present and future

These ROS impair the structure and function of enzymes that regulate sarcoplasmic calcium levels, and through a chain reaction of free radical oxidation, including a decrease in the activity of antioxidant enzymes and the onset of an inflammatory response, may lead to lipid peroxidation and protein oxidation 69

Melatonin attenuates potato late blight by disrupting cell growth, stress tolerance, fungicide susceptibility and homeostasis of gene expression in Phytophthora infestans

Naturally, the organism has several antioxidant defenses to protect against hostile oxidative environments, including classical antioxidant enzymes for example catalase, glutathione peroxidase, and superoxide dismutase as well as non-enzymatic ROS scavengers, such as -carotene, vitamin C, vitamin E, and uric acid (Espinosa-Diez et al., 2015

3.2.3 Study on the role of glutathione Glutathione (GSH), as the main intracellular antioxidant, is important in maintain the oxidative-reductive balance within cells