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As mentioned, a collection of more than 80 distinctive targets revealed many distinctive NO-system presentations at the investigated targets, giving many distinctive typical responses of NO-agents [11,29] and distinctive NO-system clusters [3,11,29] (Table 3)

Long-term use (longer than a few weeks) of systemic corticosteroids the kind you take by mouth can cause serious side effects, such as: Increased appetite and weight gain Muscle weakness Easy bruising Increased risk of infection Acne Osteoporosis (bone thinning or weakening) Onset of diabetes (or worsening if you already have it) Onset of high blood pressure (or worsening if you already have it) Trouble sleeping Therefore, your doctor will prescribe them only when you really need them, for instance, when you have a lot of joint pain and swelling

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