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Acid reflux is a symptom of GERD (gastroesophageal reflux disease), where stomach contents flow back into the esophagus, causing discomfort

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Depletion of plasma membrane-associated phosphoinositides mimics inhibition of TRPM7 channels by cytosolic Mg 2+ , spermine, and pH

It differs from the processes of apoptosis and autophagy in its particular mechanism of action and physiological significance [61]

To address this, combining gene-editing tools (e.g., CRISPR or RNAi) with conventional therapies offers a promising solutionenabling precise disruption of redox-regulating genes (e.g., NOX4 and HIF1) while leveraging the broad cytotoxicity of chemotherapy