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Int J Hematol (2001) 73(3):2717.10.1007/Bf02981951 100 SchaeferTSSandersLKNathansD

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The net effect is to enhance arousal and compulsive behavior.On the other hand, Sleep disturbances lead to elevated ghrelin with decreased levels of leptin that directly increase the activity of the orexin system, affecting the animals sleep wakefulness state and their complete behavior