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In general, it has been reported that: lidocaine and bupivacaine are most chondrotoxic greater concentrations of lidocaine and bupivacaine (i.e., 2% vs 1% and 0.5% vs 0.25%) are more toxic to chondrocytes, and greater exposure is more toxic

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They do require distribution systems, however, and recent studies reveal the roles that the iron chaperones play in maintaining cellular iron balance and utilization (Patel et al., 2019)

Science 303 , 13521355 (2004)