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doi: 10.1016/j.freeradbiomed.2023.08.020

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An advanced comprehension of the basic biology of CHAC enzymes, derived from rigorous biochemical and genetic studies, is therefore a prerequisite for their rational therapeutic exploitation

Since the simple act of feeding induces ER stress independent of dietary fat content, at least in the liver (Gomez and Rutkowski, 2016), it is possible that the consequences of obesity on ER function depend on whether or not the stimulus is experienced as accelerated feeding and fasting cycles, as in ob/ob mice, or as more calorically potent episodes of feeding with relatively normal frequency

Diabetes and vitamin B12 deficiency are two of the most common

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