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It should be noted, however, that ALDH1A1, but not CYP2E1, is a downstream target of NRF2, which was found to be activated in untreated GCLM KO mouse liver

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Patients with gastric cancer with elevated CEA and NNMT had significantly poorer prognosis than those with only one positive marker, suggesting that combining NNMT with other biomarkers improves clinical diagnostic accuracy (43)