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Other antioxidant systems In addition to GPX4, VKH 2 , and CoQH 2, which act as scavengers for free radicals, ferroptosis can also be mitigated by antioxidants such as -tocopherol [44], superoxide dismutase (SOD), and catalase (CAT) through efficient neutralization of ROS

The latter is a structure formed by the local rearrangement of host cytoskeleton enriched in the aforementioned proteins that gives the bacterium an anchoring point and enables the triggering of the signaling required for meningococcal internalization (Merz et al., 1999)

that is, the virus interferes with autophagosomelysosome fusion

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Assay optimization

Treatment with positive control auranofin (AF), a covalent TGR inhibitor with schistosomicidal activity 18 , decreased GSH/GSSG ratio by 90%