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The cleavage of the scissile bond of substrates as oxytocin and vasopressin is anticipated to take place after a nucleophilic attack by water assisted by the carboxylate function of Glu465 in the active site of IRAP

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At the molecular level, these changes are principally determined by hypoxia-inducible factor (HIF)mediated reshaping of the transcriptional profile, which depends on the extent, duration, and severity of hypoxia and by unfolded protein response (UPR)modified translational program activated in conditions of severe hypoxia/anoxia [4, 5]

Gene Therapy Approaches: While still far in the future, understanding the genetic basis of SD opens the possibility of correcting underlying genetic defects [4]

Q8: Can these chews be used alongside the OcluVet Eye Drops