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Funding This work was financially supported by grants from the National Key R&D Program of China (2023YFA1801200), the National Natural Science Foundation of China (U23A20475, 32288101, 82300574, 31871436), CAMS Innovation Fund for Medical Science (2019-I2M-5-066), and Shanghai Municipal Science and Technology Major Project (2023SHZDZX02, 2017SHZDZX01)