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Mol Pharm 16:907913

Topical BAK was studied in a randomized placebo-controlled trial, and a small but statistically insignificant ( P = .053) benefit was seen in the BAK arm after 4 weeks of therapy, as measured by the European Organisation for Research and Treatment of Cancer CIPN20 quality-of-life questionnaire.[67] Notably, statistically significant ( P = .021) improvement was seen in the motor subscale of this survey with use of BAK

However, immunogenicity, high production costs, and regulatory barriers impede their clinical adoption

Alantolactone suppresses inflammation, apoptosis and oxidative stress in cigarette smoke-induced human bronchial epithelial cells through activation of Nrf2/HO-1 and inhibition of the NF-B pathways

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