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Low levels of 5-MTHF in the brain result in impaired transport of folates across the blood-brain barrier, which has been shown to result in cerebral folate deficiency (CFD)

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Clinical Status Human RCT | Observational | Animal | In vitro Primarily studied in preclinical and exploratory neurophysiological research contexts, with limited controlled human trials

doi: 10.1016/J.RVSC.2011.11.008 126 TriantaphyllopoulosK

You may start feeling better and more energized after a course of vitamin B12