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Zheng Y, Fornelli L, Compton PD, Sharma S, Canterbury J, Mullen C, Zabrouskov V, Fellers RT, Thomas PM, Licht JD , Senko MW, Kelleher NL

Inhibiting EGR1-induced HMOX-1 or activating PPAR also suppresses ferroptosis in Kupffer cells [47, 83]

On the other hand, consuming high amounts of saturated fats and cholesterol may raise testosterone

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However, under oxidative stress, Keap1 is activated abnormally, which leads to the destruction of the interaction between Nrf2 and antioxidant response elements, thus participating in the regulation of ferroptosis