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Harper WJ, Carmona de Catril A, Chen JL: Esterases of lactic streptococci and their stability in cheese slurry systems

(2019) 177(3):55671.e16

Our work provides an understanding of how age-associated cognitive decline in older humans is linked to glutathione deficiency, increased oxidative stress, mitochondrial dysfunction, abnormal glucose metabolism and insulin resistance, inflammation and low levels of neurotrophic or neuron-supporting factors, and that supplementing GlyNAC reverses these defects and improves cognition. Human studies only permit measurements at the whole-body level, so in this study the researchers studied mice to investigate defects directly in the aging brain

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C HK-2 cells treated with MCTR1 (100 nM) and LPS (1 ug/ml) for 8 h, and the visualization of cell viability were evaluated by phase-contrast microscopy

Much of that benefit is reported anecdotally and has not been confirmed in large, rigorous human trials