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Associated symptoms of B12 deficiency include: Fatigue Pale or yellow skin Headaches Depressive symptoms Gastrointestinal symptoms Difficulty concentrating and other impaired cognitive function Cognitive decline Pain and inflammation of mouth and tongue Paresthesia (burning or pins & needles sensation) in hands and feet Muscle cramps and weakness Impaired coordination Erectile dysfunction Vision issues Lets break some of these down

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Association of biochemical B12 deficiency with metformin therapy and vitamin B12 supplements

Most tissue-specific autoantigens are hormones or hormone precursors, for example, insulin and thyroglobulin (Tg), or enzymes, for example, glutamic acid decarboxylase and thyroid peroxidase

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The present study indicated that administration of OMZ increased levels of oxidative stress by enhancing MDA levels with enhanced levels of inflammatory markers, i.e., TNF- and IL-6 in the midbrain and cerebral cortex