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In HCC patients, canonical TAM subsets (e.g., SPP1 + TAMs) promote tumor progression through the secretion of factors including macrophage migration inhibitory factor (MIF) and secreted phosphoprotein 1 (SPP1/osteopontin)

This means that if you cook your red meat at high temperatures, in which it is burned, then it might become carcinogenic but it does not mean that red meat itself is inherently carcinogenic

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