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The FDA does not recognize BPC-157 as a legal supplement, and it cannot be sold as one

Reported side effects Mild local irritation or discomfort at the injection site Headache (typically mild and short-lived) Nausea or dizziness in some patients Sweating Mild fever more commonly reported in post-stroke use, generally manageable with standard antipyretics Contraindications Cerebrolysin is not recommended for individuals with: Active epilepsy or seizure disorders Severe renal (kidney) impairment Known hypersensitivity to any component of the formulation Note: A 2023 Cochrane review noted a potentially higher rate of spontaneous adverse events in some stroke trial subgroups

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However, formulators should avoid high concentrations of chelating agents such as EDTA, as they may interfere with copper binding

Furthermore, SYNCRIP depletion resulted in a marked decrease in intracellular NAD + levels, a crucial cofactor required for the enzymatic activity of the NAD + -dependent deacetylase SIRT1 (Figure S4F-H) [27]

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