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Despite having distinct clinical presentations, both conditions are characterized by intricate inflammatory processes (Figure 2)

Evidence-Based Comp Alt Med 2011:531053

Conclusions: Although GPX3 may not directly influence immune checkpoint pathways, its high expression in myeloid cells and fibroblasts suggests that it might indirectly modulate immune responses by regulating the tumor microenvironment

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doi: 10.1007/s11707-016-0605-0 24 BuiL

Safety, efficacy and tumor mutational burden as a biomarker of overall survival benefit in chemo-refractory gastric cancer treated with toripalimab, a PD-1 antibody in phase ib/ii clinical trial NCT02915432