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doi:10.1016/j.mehy.2012.11.029 Jeong SH, Kim JS, Shin JW, et al

It particularly interferes with the REM (Rapid Eye Movement) stage, which is vital for mood regulation and memory

In order to study the diverse effects that APOE4 expression has on the brain, we performed a transcriptomics analysis on the entorhinal cortex (EC) and primary visual cortex (PVC) of 1415 month-old APOE targeted replacement mice, which express human APOE in place of their mouse Apoe gene and which do not develop overt AD pathology 28,29

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Schmidt MW, Baldridge KK, Boatz JA, Elbert ST, Gordon MS, Jensen JH, Koseki S, Matsunaga N, Nguyen KA, Su SJ, Windus TL, Dupuis M, Montgomery JA (1993) General atomic and molecular electronic structure system