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Overall, these problems cause more health issues than deaths, and the prognosis is generally favorable once individuals are no longer exposed

Conversely, patients who carry variants in hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13, rs72613567) and mitochondrial amidoxime-reducing component 1 (MARC1, rs2642438) are more protected than the general population (48, 49)

Phenotype at establishment of Wilsons disease was mostly neurologic/psychiatric (n=13), with (n=5) and without concomitant liver disease (n=2) and without investigation of liver disease (n=6)

(1) Methodology for Estimating Demonstration Costs for FY 2024 Consistent with the general methodology from previous years, we are estimating the costs of the demonstration for the upcoming fiscal year, and proposing to incorporate this estimate into the budget neutrality offset amount to be applied to the national IPPS rates for the upcoming fiscal year, that is, FY 2024

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