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Particularly, the major issue, in the case of Se, in the translation from bench to bedside, is the narrow window from therapeutic effect to toxicity due to the small margin of dosage error [73]

M., Lin, Y

Oxidized thioredoxin (Trx-S2) can be reduced by NADPH through the catalytic action of the TrxR (113)

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The tumor suppressor gene phosphatase and tensin homolog deleted on chromosome 10 ( PTEN ) inactivation by oxidation is perhaps the finest illustration related with cancer growth [26, 27]