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Current research suggests that the most effective strategies for reducing chronic sympathetic activation, and enhancing vagal tone include: Consistent, high-quality sleep Regular aerobic exercise Slow diaphragmatic breathing (particularly with prolonged exhalation) Meditation and mindfulness practices These interventions have demonstrated benefits for autonomic balance and are often associated with increased heart rate variability (HRV), a commonly used marker of vagal activity

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doi: 10.1016/j.idairyj.2021.105009 16

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Given that the main O 2 -consuming cells in the brain are neurons 55 , increased O 2 in the NuAc mainly represents the energetic cost of neuronal activity

10.1111/epi.13011 5 BuldakL.Dulawa-BuldakA.LabuzekK.OkopienB