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TVB-2640 (FASN Inhibitor) for the Treatment of Nonalcoholic Steatohepatitis: FASCINATE-1, a Randomized, Placebo-Controlled Phase 2a Trial

The conversion of glyoxylate to oxalate by the enzyme lactate dehydrogenase is inhibited by oxalate.[87] Hence gloxylate, derived from glyphosate breakdown, would accumulate in the presence of excess oxalate

A footprinting experiment performed on dinucleosomes revealed a similar enhanced cleavage of the linker region in the presence of mutant forms of H1.4 (Supplementary Fig