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Extended in vitro expansion and genetic modification of MSCs carry inherent risks of genomic instability, including chromosomal abnormalities and acquired mutations, which may compromise clinical safety

Temporary headache or dizziness (reported with limited human use) Safety Considerations None of the significant toxicity indicators were reported in the preclinical tests

Manufacturers should act now to review their entries and take advantage of key deadlines that may help avoid unnecessary charges

doi: 10.3390/ijms22031357 91 KoevoetsI

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After experiencing firsthand the impact that poor medical care can have on a patient and family, he endured more than 18 months of rehabilitation and recovery