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Furthermore, the regular measurement of serum vitamin B12 concentrations in all patients at risk (e.g., people using metformin) may cause unnecessary costs in the long term, which needs to be weighed against the costs of vitamin B12 treatment

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However, most studies have focused solely on its involvement in signaling pathway regulation, neglecting its association with Gln metabolism, and even failing to elucidate its mediating role in Gln-modulated redox homeostasis in tumor cells

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