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These observations created the initial hypothesis of prominent astrogliosis as an early event in the time course of pathology in the AD continuum 354

Preliminary clinical studies suggest CoQ10 (300400 mg/day) improves fatigue and sleep disturbances, but larger trials are needed for confirmation

Tomaszewski et al., 2015)

Montgomery SL, Bowers WJ (2012) Tumor necrosis factor-alpha and the roles it plays in homeostatic and degenerative processes within the central nervous system

PMCID: PMC1994217

Although no research has yet established a direct link between lactylation modifications and MS, this area holds significant exploratory potential